Instrument: Precellys® 24 Dual
A significant increase of the Ketoprofen dissolution rate is observed after co-micromilling using various excipients, compared to non micromilled material. This increase is observed for excipients which have or do not have solubilizing properties (surfactant vs PVP derivatives)
Significant particle size reduction is observed for comicromilled formulations such as Crospovidone-Ketoprofen. Drug dissolution following comicronisation has been significantly improved. No amorphisation of the API was found after the process.