Bullet Blender® 50 DX

Category Bead Mill Homogenizer
Manufacturer Next Advance
Country of manufacture the United States
Average customer rating based on 1 review

The Bullet Blender 50 DX enables you to homogenize, disrupt, or lyse up to 8 large tissue or cell culture samples (up to 3 mg solid weight, 10-15 ml total volume) at a time in standard 50 ml polypropylene screw-cap tubes. Load the samples into the tubes, place them in the Bullet Blender, set the time and speed and you're ready! The "bullets" in the instrument vigorously strike all of the tubes and homogenize your sample in minutes.

The Bullet Blender 50 DX also incorporates air cooling to dissipate heat.  The air cooling draws circulates ambient air into the Bullet Blender, maintaining samples at ambient temperature.  (Tip: Place the Bullet Blender 50 DX in a cold room to keep samples near 4°C!)

Consistent Results

The Bullet Blender 50 DX allows homogenization of large samples (up to 3.5 g) and prepares up to 8 samples in just minutes. All of the samples are automatically homogenized in the same manner to minimize sample-to-sample variability.

No Cross-Contamination or Sample Loss

There are no probes or blades to cause cross contamination or sample loss, which also means there are no parts to clean between runs. The sample tubes are kept closed and self-contained during homogenization.

Samples Stay Cool

The instrument uses very little power due to the unique, patented design, so there is very little heat build up in the instrument or inside the sample tubes, and a cooling fan helps keep samples very close to ambient temperature. It uses a DC motor to agitate the individual tubes.  The Bullet Blender is designed for reliability and durability, with few moving parts and a very low rate of motor wear.

Easy To Use

Simply place your sample, beads and buffer in standard tubes, and load the tubes into the Bullet Blender. Tune the extent of disruption by adjusting the run time and speed. Afterwards, place the sample tubes in a centrifuge to separate the lysate. No special holders are needed. There are no clamp plates nor locking rings to fiddle with.

Risk Free Purchase

All Bullet Blenders include a 30 day money back guarantee and a 2 year warranty.


 DNA RNA Protein

from Plant Samples

from Animal Samples

from Microbial Samples


 Genomic DNA samples in agarose gel stained with ethidium bromide.

Lanes 1-4 = Tobacco leaf DNA

λ = phage λ Hind II digest

Lanes 5-8 = Rice leaf DNA

Total RNA gel from mouse tail snips.

RNA integrity number = 8.5

Data courtesy of  Madhu Prasad @ U. Michigan

E. coli sample.

SDS Page gel stained with coomassie blue.

wc = whole cell.  sf = soluble fraction.

Left two lanes control. Right two lanes induced.

Key Attributes
Homogenizer Type Bead Mill
Sample Throughput 8 samples
Sample Volume (min) 100 µl
Sample Volume (max) 10 ml
Usage / Placement Benchtop
Cooling Yes
Warranty 2 years
Noise Level 100 dB
Weight 33 lb
Width 15"
Depth 14"
Height 15"

What is the RPM range of the Bullet Blender 50 DX?

Next Advance does not disclose the RPM specifications for the Bullet Blenders. The reason they do this is because the mechanism of action for the Bullet Blenders (striking) is very different from the mechanism of action for other laboratory bead mill homogenizers, which almost exclusively act via shaking. Direct comparisons with different bead mills from different manufacturers based on RPMs, including using protocols from other instruments based on RPM, are not possible.

The best we can tell you is that the speed setting "1" is a speed which would be good for a moderately vigorous mixing, and the maximum speed is the most power you will get from the instrument. The specific RPMs which correspond to the numbers on the dial are not documented by Next Advance.

If you have questions pertaining to the processing power of the Bullet Blender 50 DX, please contact us for more information.


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Customer reviews

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Bullet Blender® 50 DX Accessories