Micro DeBEE High Pressure Homogenizer

Category High-Pressure Homogenizer
Manufacturer BEE International
Country of manufacture the United States of America

The capabilities of the larger DeBEE Homogenizers in a portable, cost-effective unit. Obtain the exact particle or droplet size required with a low D(0.9). Or, disrupt the toughest cells with the highest yield. So advanced, it's actually simple!

Air Operated Ultra High Pressure Homogenizer with Modular Homogenizing Cell. Capable of the Highest Processing Intensity. No Moving Parts in Homogenizing Cell. Unmatched Results - Size Reduction to Nanometers. Cell Rupture with the Highest Yield. Inherently Explosion Proof. Additional Nozzle Sets Included. 

The 5 liters per hour user-friendly Micro DeBEE is suitable for a wide range of applications, including Cell Disruption, Particle Size Reduction, Nano / Micro Emulsions, Nano / Micro Dispersions, Polymers, and Liposomes.  The core technology - BEEI's proprietary homogenizing cell - ensures excellent results in fewer passes. 


  • Easy to use, Micro DeBEE laboratory homogenizer features include:
  • Up to 30,000 PSI / 3,100 Bar 
  • 100% guaranteed scalability of results
  • Easy cleaning and maintenance with no disassembly required
  • Unmatched experimentation options
  • Suitable for sanitary applications
  • Minimum sample size as low as 5 ml
  • Modular Emulsifying Cell (EC) is configurable with multiple flow patterns for a broad range of applications.
  • CE Compliant
  • Lifetime training for new employees and students
  • 1-year factory warranty
  • Lifetime training available to help new employees and students get up to speed quickly.
  • Capacity 250 (ml / min) / 15 (l / hr)

Lead Time 2 - 4 weeks

The Micro DeBEE high-pressure homogenizing system combines the homogenizing forces of most other homogenizers into a single instrument:

  1. Before passing through the nozzle, a turbulent flow may be created to vigorously premix the product (like stirrers and agitators).
  2. A large pressure drop upon exiting the nozzle causes cavitation (like ultrasonic homogenizers).
  3. The product, which is travelling fast enough to cut metal, then impacts the end fixture in the Emulsifying Cell, creating a strong physical force (like bead mills).
  4. Shear forces are present throughout the Emulsifying Cell due to changes in relative velocity in the moving liquid.  These shear forces are higher than in rotor-stator homogenizers.

All of the above forces may be adjusted in the Micro DeBEE, allowing for highly customized operation in order to achieve the desired particle size in a highly reproducible manner with minimal passes and processing time.

PLEASE NOTE: The Micro DeBEE requires a source of pressurized, clean, dry air in order to run. See the manufacturer specifications tab for more information.

Key Attributes
Homogenizer Type High Pressure
Sample Throughput 1 Sample
Sample Volume (min) 5 ml
Sample Volume (max)
Usage / Placement Benchtop
Cooling Yes
Warranty 1 year
Noise Level N/A
Weight 70 lbs
Width 34"
Depth 14"
Height 18"
Manufacturer Specifications

Continuous flow up to 250 ml/min
Operating pressure: 2,000 to 30,000 PSI (150-2,000bar)
Air supply (not included with purchase) must be clean, dry air with 0-35°F Dew Point.
Adjustable back pressure: 0 to 5,000 PSI
Dimensions: 34”W x 14”D x 18”H (865 x 356 x 460 mm)
Weight: 70 lbs. (32Kg.)


This is a big decision. Can we try a Micro DeBEE before we purchase it?

Yes, for a fee. If your samples are in no way hazardous Micro DeBEE can test and optimize your high-pressure homogenization process for you, provide an on-site demo, or you can lease a unit for one to two months. If you're interested in any of those options, shoot us an email or give us a call and we'll be happy to discuss costs and help set it up.


What is the maximum viscosity substance that the Micro DeBEE can handle?

Very high. Well over 20,000 cps. The rule of thumb with the Micro DeBEE is that if it's liquid and you can pump it, you can homogenize it in the Micro DeBEE. At very high viscosities, however, you may need to use air pressure to feed the sample into the machine.

If we had to draw a line, it would be at 100,000 cps.


What is the procedure for cleaning or sterilizing the Micro DeBEE?

Most users simply run a suitable solvent through the system. Done properly, this is generally satisfactory to meet regulations pertaining to the sterilization of instrumentation (FDA, etc.).


It seems like this is too good to be true. You get a much higher flow rate than with the Nano DeBEE but at basically the same cost. What's the catch?

The Nano DeBEE is a complete system - it does not require anything else to operate. The Micro DeBEE requires a source of clean, dry, pressurized air. Therefore, while the price for the instrument itself seems great, the cost of a large air compressor and dryer increases the total system cost substantially. Additionally, air operated units are much louder which many customers dislike. Otherwise, the Micro DeBEE is certainly an attractive option.


I am trying to homogenize gas into a liquid. Would the Micro DeBEE be suitable for my application?

No. Products which may contain significant amounts of gas should be degassed before homogenization in the Micro DeBEE. Gas bubbles in the feed fluid implode when pressure is generated, which creates water-hammer effect or extreme pressure spikes that are detrimental to the equipment.


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