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Post-mortem Redistribution of Drugs in Rats

Instrument: Precellys® 24 Dual

Sample:  Rat Heart

Protocol:

  • Precellys kits: CK14 (small ceramic beads)
  • Sample : rat heart (1/2 v/v)
  • Buffer : water
  • Run the Precellys®24 at 6500 rpm, 2x15 sec.

Results:

Those chromatograms present liquid-liquid extraction results obtained from heart samples 6 hours after death. At this time the concentration of haloperidol and thioridazine was respectively 472 ng/g and 1435 ng/g (significant variation).

 

The Precellys®24 allows a quick and efficient homogenization on a significant number of samples. The homogenate is perfectly appropriate for drug extraction.