Post-mortem Redistribution of Drugs in Rats
Instrument: Precellys® 24 Dual
Sample: Rat Heart
Protocol:
- Precellys kits: CK14 (small ceramic beads)
- Sample : rat heart (1/2 v/v)
- Buffer : water
- Run the Precellys®24 at 6500 rpm, 2x15 sec.
Results:
Those chromatograms present liquid-liquid extraction results obtained from heart samples 6 hours after death. At this time the concentration of haloperidol and thioridazine was respectively 472 ng/g and 1435 ng/g (significant variation).
The Precellys®24 allows a quick and efficient homogenization on a significant number of samples. The homogenate is perfectly appropriate for drug extraction.
