Precellys® 24

Overview

The Precellys® is a powerful, high-throughput bead mill homogenizer, capable of homogenizing up to 24 samples with a typical run time of just 30 seconds for most samples.  Tough samples such as cartilage, hair, skin, or even bone can be efficiently homogenized in the Precellys.  Nucleic acid or proteins are separated from the tissue matrix and can be pipetted off after a short centrifugation step to pellet the debris.

The Precellys utilizes a figure-8, multi-directional motion which conveys a very high kinetic energy to the beads, causing intense collisions which break apart samples.  In many homogenizers, mechanical impacts between beads or between beads and the sample can generate heat. With the Precellys 24, the homogenization process is so fast that the temperature does not reach denaturation levels.

The Precellys has established protocols and various consumables for the processing of soft tissues, hard tissues, or microorganisms.  Users can simply change the speed and beads to accommodate a number of applications, such as:

• Dry grinding
• Micronisation
• Homogenization from fresh or snap-frozen tissues
• Lysis of micro-organisms
• Dissociation of living bacteria

The Precellys has been designed specifically for biological sample preparation.  Processing space is sealed off from the mechanical parts preventing any inside contamination, and individual sealed tubes prevent cross contamination between samples.  Once your protocol is validated, the sample preparation process remains exactly the same with no variability.  The Precellys was specifically developed and designed to be used in a BSL3 laboratory under high throughput conditions: 50 to 100 runs per day.

A 1-year warranty is standard with the Precellys.  Extended 2-year or 3-year warranties are optional.  For each additional year of warranty, a maintenance kit is provided which includes 2 vacuum joints, 1 anti-rotation tubing kit, and 1 containment seal.

The Precellys 24 is capable of homogenizing 24 samples of up to 1 g / 1.6 ml simultaneously in 2 ml tubes.  If you have highly temperature sensitive samples and require that your homogenization is performed under refrigerated conditions, take a look at the Cryolys accessory, which maintains samples at approximately 4°C.

Want the power but don't need the throughput?  Take a look at the inexpensive Minilys.  Want even more power and the flexibility to accommodate larger samples?  Check out the Precellys Evolution.

Key Attributes

Manufacturer Specifications

Precellys 24:

• Applications: tissue from 1mg to 500mg – Cell culture from 10µL to 1500µL
• Capacity: Up to 24x2mL
• Run time: 5 - 90 s by 5 s increments
• 3D motion speed: 5000 - 6800 rpm by 100 rpm increments
• Number of cycles: 1 - 3
• 5 user programs
• LCD with back light up to 2 lines - four button keyboard
• Dimensions : 290 (L) x 375 (W) x 370 (H) mm 600 mm (H open cover)
• Weight : 29,8 kg
• Operating temperature : 4°C to 30°C
• Universal Power : 100 - 230 VAC / 50 - 60 Hz
• FCC Part 15 and CE compliance

FAQ

What are the primary differences between the Precellys 24 and the Precellys Evolution?

There are three main differences:

1. ​Power. The Precellys Evolution has almost 50% higher max RPM than the Precellys 24.
2. Flexibility with regards to sample size. The Precellys 24 holds 24x 2ml tubes. The Precellys Evolution also comes with an adapter that does the same, but there are additional, optional adapters that hold either 12x 7 ml tubes or 6x 15 ml tubes, allowing processing of larger samples.
3. If you're interested in keeping samples cool, the Cryolys cooling unit is much better for the Precellys Evolution. The Cryolys for the Precellys 24 is a standalone item which takes up about an equivalent amount of bench space to the Precellys 24 and requires a compressed air connection (or house pressurized air). The Cryolys for the Precellys Evolution is a relatively small "cap"-like device which sits on top of the Precellys Evolution so it doesn't take up any additional bench space and it does not require an air hookup.

 ... and of course there's the cost difference.

What are the safety features of the Precellys 24 which make it suitable for BSL-3 labs?

1. Top and pressure alarm: If the lid is not securely closed or the blocking plate is not placed correctly on the tube holder to lock the samples in place, the unit will not start the run.
2. Compatibility with vaporized hydrogen peroxide decontamination (see picture below). Vaporized H2O2 can be used to decontaminate the unit in case of tube breakage.
3. Containment seal which isolates the homogenization chamber from both the external environment and the internal mechanical parts.